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(For a scientist, it is a unique experience to live through a period in which his field of endeavor comes
to bloom — to be witness to those rare moments when the dawn of understanding
finally descends upon what appeared to be confusion only a while ago — to
listen to the sound of darkness crumbling)
George Emil Palade- The Father of Cell Biology
Here you are
going to know about a man who has contributed to your syllabus pretty
much. The one who has worked with so
much dedication to make the Biological Studies more lengthy.
George Emil Palade, the father of Cell Biology
and also a pioneer of Modern Cell Biology. He was born on 19 November 1912 at
Laśí, Romania and worked harder for us till 7 October 2008 at Del Mar,
California, United States (died).
He was the
most influential cell biologists.
He worked in
field of Cell Biology. Also made contribution in better Centrifugation
Techniques and Microscopical Cell Studies along with giving a way in Cell
Fractionation.
Research Areas:
Most
important and turning point was his experiment where he used Pulse Chase
Analysis and confirmed that RER and Golgi Apparatus work together for protein
synthesis. Thereby he cleared the doubt
regarding the Secretory Pathway from ER to Golgi. That experiment also confirmed that besides multiple fusions of membranes of ER and Golgi, there is a critical
difference between these membrane-bound cell organelles (1995).
Another milestone was the discovery of the Weibel-Palade bodies (1964). Palade worked with
Ewald Weibel and spotted these bodies inside the Endothelial cells, these
bodies are now considered as distinguishing markers for Endothelial cells from
other types of cells. These bodies are unique to Endothelial cells. They are
related to the blood coagulation system. These bodies of granules contain
vasoconstrictor Endothelin, Tissue Plasminogen Activator, and P-selectin.
George
Palade has given a comparative study of membranes of the Golgi apparatus, Zymogen
granules, Plasma membrane, Microsomes and concluded that they differ in lipid
and protein composition. He also founded that Golgi is rich in cis- and trans-
Golgi elements.
While
working with Lucian Caro on exocrine Pancreatic cells, Palade described the functional role of the Golgi Apparatus in the condensing and processing of Protein.
Some bagged Achievements:
ü Degree in Medicine from the University of
Bucharest, 1940.
ü Albert Lasvar Award for Basic Medical
Research, 1966.
ü Gardner Foundation International The award, 1967.
ü Louisa Grow Horowitz Prize from Columbia
University, 1970.
ü Shared Nobel Prize in Physiology and
Medicine (1974) with Albert Claude and Christian de Duvé.
ü E. B. Wilson Medal, 1981.
ü National Award for Science, 1986.
Designations:
ü Elected Member of National Academy of
Science, 1961.
ü Honorary Fellowship of Royal
Microscopical Society, 1968.
ü Foreign Member of Royal Society,
1984. (ForMemRS)
ü Member of Faculty at Card Davia
University until 1946.
ü Later joined Albert Claude at
Rockefeller Institute for Medical Research.
ü Professor at Yale University Medical The school (1973-1990) and University of California, San Diego (1990-2008).
ü Dean for Scientific Affairs in School
of Medicine at LA Jolla California.
ü Founding Member of World Cultural
Council, 1981.
Summary:
George Emil
Palade has been a consistent scientist in the field of Cell Biology. He has worked with many great Scientists and
influenced them to work better. One of his students, Gunter Blobel has also contributed to the field of cell
biology (protein transport).
Without his
work our syllabus could have been much less, but our understanding of cellular
organelles could also have been unsolved and in dark.
Books to Explore Cell Biology:
1. Cell Biology 7th edition by Gerald
Karp
2. The Cell A Molecular Approach 6th
edition by Geoffrey M. Cooper and Robert E. Hausman
3. Molecular Biology of The Cell 5th
edition Reference Edition by Albert, Johnson, Lewis, Raff, Robert, Walter.
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